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The erythrocytes are capable of reducing metHb to functional Hb through methemoglobin reductases and of detoxifying the cell from H 2 O 2 through the glutathione metabolism [2]
(1 Injection Set = 2 ampoules + 1 vial)
These important interactions are beyond the scope of this initial investigation, but will be incorporated in future studies
GSH could be converted to its oxidized form, called glutathione disulfide, by glutathione peroxidase which decomposes ROS to H 2 O and O 2 , and the glutathione disulfide is then regenerated to GSH by glutathione reductase at the expense of NADPH [16, 17]
The release of glutamate from vesicles can either be dependent on external Ca 2+ or on Ca 2+ release from intracellular stores (Bezzi et al., 2004